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Newrotex develops innovative silk-based medical
solutions for the nervous system.
Newrotex develops innovative silk-based medical
solutions for the nervous system.
The answer to “Can you repair nerves?” shouldn’t come with caveats. This is why Newrotex is set to disrupt existing approaches to surgical nerve repair. We’re on track to provide an alternative to autografts, the current gold standard in treatment for nerve injuries. A gold standard that requires sacrificing a healthy nerve from another part of the body. With our patented silk-based technology, we’ll deliver an off-the-shelf solution for surgical repair of the nerve. Without the need for long, complicated operations or using expensive donor tissues, Newrotex makes immediate treatment possible for patients who have suffered nerve injuries due to trauma, medical conditions, or surgical treatments.
Annual operations for nerve injuries
Newrotex silk-based nerve products address the shortcomings of the solutions currently available.
Most of the world’s 1.5 million annual operations for nerve injuries are treated with autografts requiring a second injury and long surgery times, along with risking donor site morbidity and infection.
All of the major current solutions – autografts, allografts, and hollow tube conduits – are limited when repairing large gaps in nerves. Read Current Approaches for more about these and other shortcomings with current solutions for peripheral nerve repair.
Over the past few decades, the potential biomedical applications of silk have been gaining interest at an exponential rate.
The versatility created by silk’s chemical structure allows for the production of fibres, gels, scaffolds, films, membranes, and powders. Silk has shown to have excellent cell affinity, and being biocompatible, with the ability to tailor biodegradation, silk is an ideal candidate for biomedical applications.
In terms of nerve repair, luminal silk fibres inside a vein or conduit guide regenerating axons, while the bioabsorbable, permeable tube allows nutrients to support nerve regeneration. Furthermore, silk products can be stored at room temperature, thereby removing the need for expensive cold storage and transportation.
Our first product is a 10cm implant made from bundles of luminal spider silk fibres that can be implanted into a vein or inserted into hollow conduits to support nerve re-growth. Pre-clinical studies have show that SilkAxons® support superior axonal regeneration.
Our second product is an off-the-shelf silk-based peripheral nerve conduit pre-filled with enhancing luminal silk fibres, negating the need to use a vein.
The fibres have proven nerve-regenerating properties and clinical trials show them to be comparable or superior to autografts. And with a porous tubular biocompatible sheath designed to encourage vascularisation, we provide a new and better approach to treating patients with peripheral nerve injuries.
Newrotex launched a first-in-human clinical trial in Q3 2025 using SilkAxons® to bridge large nerve gaps of up to 10cm (significantly more than current FDA approved devices). This study will generate foundational data for Newrotex’s global clinical strategy. Our goal is to commence a large study this year culminating in an application for market approval in the USA and UK. We are also developing collaborations in which our silk platform technology may lead to further improvements in patient care, such as Schwann cell delivery and spinal cord injury repair.
: While it was highly acclaimed by critics in Venice, it faced censorship battles and was largely kept out of mainstream American theaters for decades. Tinto Brass - Vacation
Through a series of free-flowing, nonlinear flashbacks, Immacolata shares her past traumas with Osiride. Entangled in a fragile emotional bond, the pair embark on a bizarre journey through a corrupt world. They encounter an array of eccentric, comical, and highly unconventional characters—ranging from local magistrates to the elite gentry—culminating in a chaotic critique of the judicial system, class inequality, and societal hypocrisy. The Cast and Key Characters
Understanding the film requires some context about Tinto Brass's work and the era in which "La Vacanza" was made. Being familiar with his thematic preoccupations and directorial choices will enhance the viewing experience.
: The film utilizes fragmented, rapid-fire editing and highly stylized camera movements. The Vacation -La Vacanza- - Tinto Brass 1971 -S...
La Vacanza tells the story of (played by Vanessa Redgrave), a peasant girl and mistress to a count, who is committed to a mental asylum after the count turns his attention back to his wife. The film centers on her one-month experimental leave from the institution—the "vacation" of the title.
In a push for authenticity, the lyrics for the film's music were actually written by inmates of mental institutions.
: It utilizes Brass's trademark quick editing and elegant zoom-shots, though it is often described as more "grounded" and reflective than his earlier, more frantic works. : While it was highly acclaimed by critics
La Vacanza occupies a unique position within Tinto Brass’s filmography. It is, as one Italian critic has noted, his last “committed” film before he transitioned to the softcore erotica that would make him famous (or infamous) throughout Europe and beyond. After La Vacanza , Brass directed Dropout (1972) and then moved into a period of greater commercial success with films like Salon Kitty (1976) and Caligula (1979). The latter, of course, became a notorious cause célèbre—Brass was famously fired from the project and his work was drastically re-edited without his consent, turning his intended satire on power into a hardcore pornographic epic. Disowning the final product, Brass retreated into independent, low-budget erotica for the remainder of his career.
Upon its release in Italy, La Vacanza was largely overshadowed by Pasolini’s The Decameron and Bertolucci’s The Conformist , both released the same year. Critics at the time found it “too slow” for a Brass film and “too explicit” for an art film. Today, however, it has gained a cult reputation among Brass aficionados and students of European erotic cinema.
The film follows (played with weary detachment by Franco Nero , in a role that subverts his usual heroic cool) and his younger, volatile lover, Gigi (a magnetic Florinda Bolkan ). Seeking to escape the claustrophobic chaos of a Rome simmering with political protests, the couple retreats to a remote, rustic villa on the Sardinian coast. Their stated goal is a “vacation”—a pause to reconnect. They encounter an array of eccentric, comical, and
In the vast, often misunderstood filmography of Tinto Brass, the 1971 film holds a peculiar place. Sandwiched between his early forays into political satire ( Nerosubianco ) and his later, more famous forays into softcore erotica ( Caligula , The Key ), La Vacanza is a film of transitional tension. It captures the director in a moment of stylistic refinement, where his love for the human form begins to collide with a distinctly post-’68 sense of emotional disillusionment.
The story follows Immacolata (Vanessa Redgrave), an inmate at a psychiatric hospital who is granted a temporary leave—a "vacation"—to see if she can reintegrate into society.